منابع مشابه
Systems Analysis of Thrombus Formation.
The systems analysis of thrombosis seeks to quantitatively predict blood function in a given vascular wall and hemodynamic context. Relevant to both venous and arterial thrombosis, a Blood Systems Biology approach should provide metrics for rate and molecular mechanisms of clot growth, thrombotic risk, pharmacological response, and utility of new therapeutic targets. As a rapidly created multic...
متن کاملMechanisms of thrombus formation.
N Engl J Med 2008;359:938-49. Copyright © 2008 Massachusetts Medical Society. Hemostasis is the process that maintains the integrity of a closed, high-pressure circulatory system after vascular damage. Vessel-wall injury and the extravasation of blood from the circulation rapidly initiate events in the vessel wall and in blood that seal the breach. Circulating platelets are recruited to the sit...
متن کاملThrombus formation reimagined.
In 1882, Dr Giulio Bizzozero described the use of intravital microscopy to detect the accumulation of platelets following needleinduced injury of the mesenteric artery in rabbits and guinea pigs. Bizzozero’s paper was not only the first to define the platelet in name (“Blutplättchen” in German) but was also the first to functionally define platelets as the primary cell type contributing to thro...
متن کاملPlatelet Thrombus Formation
severe homozygous von Willebrand factor (vWF)-deficient pigs (vWF<3%) (n=6), and heterozygous vWF-deficient pigs (vWF=24%) (n=2). Thrombus formation was measured by autologous "'In-platelet labeling and by ultrastructural morphology. Heparinized and native blood from these pigs was perfused over the substrate for 3 and 5 minutes at local shear rates from 212 to 3,380/sec. On collagen type I exp...
متن کاملThrombus formation in vivo.
To examine thrombus formation in a living mouse, new technologies involving intravital videomicroscopy have been applied to the analysis of vascular windows to directly visualize arterioles and venules. After vessel wall injury in the microcirculation, thrombus development can be imaged in real time. These systems have been used to explore the role of platelets, blood coagulation proteins, endo...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2016
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.115.306824